Anti-Human IL-31 Reference Antibody (BMS-981164, RUO) (HV678016)

Name: Anti-Human IL-31 Reference Antibody (BMS-981164, RUO)
Brand: abinScience
SKU: HV678016
Price: 176 USD
Availability: InStock

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SDS

Vista general

Número de catálogo	HV678016
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
ID de clon	BMS-981164
Actividad biológica	BMS-981164 (0.01-10000 pM; 6 h) inhibits the IL-31 signaling pathway in a dose-dependent manner in PathHunter U2OS IL31RA/OSMR dimerization cells [1]. BMS-981164 (5 nM; 24 h) inhibits IL-4/IL-31-induced CCL2 secretion in human bronchial epithelial BEAS-2B cells [1].
Sistema de expresión	Mammalian cells
Objetivo	IL-31, Interleukin-31, IL31
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q6EBC2
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	BMS-981164, BMS981164, BMS981164
Fondo	Interleukin-31 (IL31) is a ~18 kDa protein. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. 1. Dillon, SR. et al. (2004) Nature immunology 5, 752-60. PMID: 15184896
Referencias	1. Tietz J, et al. A Bispecific, Tetravalent Antibody Targeting Inflammatory and Pruritogenic Pathways in Atopic Dermatitis. JID Innov. 2024;4(2):100258. Published 2024 Jan 16. [HV678016]
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Bioactivity

Detects Recombinant Human IL31 Protein, C-His (Cat No.: HV678011) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL31 (BMS-981164).