Anti-Human ADCYAP1/PACAP Reference Antibody (Ab22, RUO) (HB716026)

Name: Anti-Human ADCYAP1/PACAP Reference Antibody (Ab22, RUO)
Brand: abinScience
SKU: HB716026
Price: 370 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HB716026
説明	Anti-Human PACAP38 Antibody (Ab22) (HB716026) is a research-grade recombinant antibody targeting Pituitary adenylate cyclase-activating polypeptide. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG2
クローンID	Ab22
発現システム	Mammalian cells
ターゲット	Pituitary adenylate cyclase-activating polypeptide, ADCYAP1, PACAP, PACAP-38, PACAP38, PACAP-27, PACAP27, PRP-48
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P18509
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. 1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907 2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469 3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
注意事項	For research use only. Not suitable for clinical or therapeutic use.