Anti-Human Serpin E1/PAI-1 Reference Antibody (CT140, RUO) (HY185026)

Name: Anti-Human Serpin E1/PAI-1 Reference Antibody (CT140, RUO)
Brand: abinScience
SKU: HY185026
Price: 370 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Referencias
Datasheet
SDS

Vista general

Número de catálogo	HY185026
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4-kappa
ID de clon	CT140
Sistema de expresión	Mammalian cells
Objetivo	PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P05121
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CT140
Fondo	Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. 1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 15853774 2. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 17912461 3. Lee, MH. et al. (1993) Blood 81, 2357-62. PMID: 8481516 4. Fay, WP. et al. (1997) Blood 90, 204-8. PMID: 9207454 5. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 21925150 6. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 9175705 7. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 15001579 8. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 9168821 9. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 18386027 10. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142
Referencias	1. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chem Commun (Camb). 2015 Sep 28;51(75):14263-6. [HY185026]
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Imágenes

Western blot

Western blot analysis was performed using anti-human SERPINE1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human SERPINE1 (Catalog No: HY185012)
Lane 2: negative control
Bioactivity

Detects recombinant human SERPINE1/PAI-1 (Catalog No: HY185012) in indirect ELISA