Anti-SERPINE1/PAI-1 Polyclonal Antibody (HY185014)

Name: Anti-SERPINE1/PAI-1 Polyclonal Antibody
Brand: abinScience
SKU: HY185014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY185014

Species reactivity

Human, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SERPINE1/PAI-1 (Gly21-Pro402).

Target

PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1

Purification

Purified by antigen affinity column.

Accession

P05121

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading.

1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 15853774

2. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 17912461

3. Lee, MH. et al. (1993) Blood 81, 2357-62. PMID: 8481516

4. Fay, WP. et al. (1997) Blood 90, 204-8. PMID: 9207454

5. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 21925150

6. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 9175705

7. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 15001579

8. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 9168821

9. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 18386027

10. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SERPINE1/PAI-1 polyclonal antibody at 1ug/mL on recombinant SERPINE1/PAI-1 (Catalog No. HY185012).

References

Datasheet