Anti-Human Serpin E1/PAI-1 Reference Antibody (MEDI-579, RUO) (HY185016)

Name: Anti-Human Serpin E1/PAI-1 Reference Antibody (MEDI-579, RUO)
Brand: abinScience
SKU: HY185016
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HY185016
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
ID de clone	MEDI-579
Système d'expression	Mammalian cells
Cible	PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P05121
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	MEDI-579, MEDI579, MEDI579
Contexte	Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. 1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 15853774 2. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 17912461 3. Lee, MH. et al. (1993) Blood 81, 2357-62. PMID: 8481516 4. Fay, WP. et al. (1997) Blood 90, 204-8. PMID: 9207454 5. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 21925150 6. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 9175705 7. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 15001579 8. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 9168821 9. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 18386027 10. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142
Reférences	1. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chem Commun (Camb). 2015 Sep 28;51(75):14263-6. [HY185016]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)