Anti-Human PACAP/ADCYAP1 Reference Antibody (Bocunebart, RUO) (HB716046)

Name: Anti-Human PACAP/ADCYAP1 Reference Antibody (Bocunebart, RUO)
Brand: abinScience
SKU: HB716046
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HB716046
Description	bocunebart (HB716046) is a research-grade recombinant antibody targeting PACAP/ADCYAP1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, Kappa
Espèces	Human
Cible	PACAP/ADCYAP1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Numéro d'accès	P18509
Forme	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	2984605-64-1
Contexte	Pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. 1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907 2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469 3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Note	For research use only. Not suitable for clinical or therapeutic use.