Anti-Human Guanylyl Cyclase C/GUCY2C Reference Antibody (Indusatumab, RUO) (HB626016)

Name: Anti-Human Guanylyl Cyclase C/GUCY2C Reference Antibody (Indusatumab, RUO)
Brand: abinScience
SKU: HB626016
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HB626016
Description	Indusatumab (HB626016) is a research-grade recombinant antibody targeting STAR. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Cible	STAR, Intestinal guanylate cyclase, GC-C, GUC2C, STA receptor, Heat-stable enterotoxin receptor, Guanylyl cyclase C, hSTAR, GUCY2C
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P25092
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	5F9, MLN2045, IndusatumabVedotin(1514889-12-3, 5F9vcMMAE, MLN-0264), 1497400-26-6
Contexte	Guanylyl cyclase C (GUCY2C/GCC) is a ~123 kDa protein. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. 1. Scott, RO. et al. (2002) The Journal of biological chemistry 277, 22934-41. PMID: 11950846 2. Singh, S. et al. (1991) Biochemical and biophysical research communications 179, 1455-63. PMID: 1718270 3. Fiskerstrand, T. et al. (2012) The New England journal of medicine 366, 1586-95. PMID: 22436048 4. Romi, H. et al. (2012) American journal of human genetics 90, 893-9. PMID: 22521417 5. Arshad, N. et al. (2013) The Journal of biological chemistry 288, 3907-17. PMID: 23269669 6. de Sauvage, FJ. et al. (1991) The Journal of biological chemistry 266, 17912-8. PMID: 1680854 7. Mann, EA. et al. (1993) The American journal of physiology 264, G172-8. PMID: 8381596
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)