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| カタログ番号 | HY285016 |
|---|---|
| 説明 |
Lesigercept (HY285016) is a research-grade recombinant antibody targeting FcERI. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, Functional assay, Research in vivo |
| アイソタイプ | Human FcERI (IgE Fc receptor subunit alpha) extracellular domain fragment fused to a Fc fragment of human IgG4 |
| 発現システム | Mammalian cells |
| ターゲット | FcERI, IgE Fc receptor subunit alpha, FCER1A, Fc-epsilon RI-alpha, FCE1A, High affinity immunoglobulin epsilon receptor subunit alpha |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P12319 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 2878448-12-3 |
| 背景 | High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A/FcERI) is a ~29 kDa protein. High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Lesigercept
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