Anti-Human DLEC/CLEC4C/BDCA-2 Reference Antibody (Litifilimab, RUO) (HV560016)

Name: Anti-Human DLEC/CLEC4C/BDCA-2 Reference Antibody (Litifilimab, RUO)
Brand: abinScience
SKU: HV560016
Price: 176 USD
Availability: InStock

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Обзор

Каталожный номер	HV560016
Описание	Litifilimab (HV560016) is a research-grade recombinant antibody targeting CD303. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Система экспрессии	Mammalian cells
Цель	CLEC4C, C-type lectin superfamily member 7, CLECSF11, C-type lectin domain family 4 member C, Dendritic lectin, CD303, DLEC, HECL, Blood dendritic cell antigen 2, BDCA-2, BDCA2, CLECSF7
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q8WTT0
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	BIIB059, BIIB-059, BIIB059, 2407378-48-5
Фон	C-type lectin domain family 4 member C (CD303/CLEC4C) is a ~25 kDa protein. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. 1. Dzionek, A. et al. (2001) The Journal of experimental medicine 194, 1823-34. PMID: 11748283 2. Riboldi, E. et al. (2011) The Journal of biological chemistry 286, 35329-35333. PMID: 21880719 3. Jégouzo, SA. et al. (2015) The Journal of biological chemistry 290, 16759-71. PMID: 25995448
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Litifilimab

Ссылки

Даташит

Anti-Human DLEC/CLEC4C/BDCA-2 Reference Antibody (Litifilimab, RUO).pdf

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Formula

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