Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO) (JN961016)

Name: Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO)
Brand: abinScience
SKU: JN961016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	JN961016
Description	Omodenbamab (JN961016) is a research-grade recombinant antibody targeting SpA. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Staphylococcus aureus
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG3-Kappa
Système d'expression	Mammalian cells
Cible	SpA
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P02976
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	514-G-3, 514-G3, PA8-G3, 2241724-48-9
Contexte	Immunoglobulin G-binding protein A (SpA) is a ~56 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. 1. Graille, M. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5399-404. PMID: 10805799 2. Moks, T. et al. (1986) European journal of biochemistry 156, 637-43. PMID: 2938951 3. Forsgren, A. et al. (1966) Journal of immunology (Baltimore, Md. : 1950) 97, 822-7. PMID: 4163007
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Omodenbamab

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Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO).pdf

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