Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO) (JN961016)

Name: Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO)
Brand: abinScience
SKU: JN961016
Price: 176 USD
Availability: InStock

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Обзор

Каталожный номер	JN961016
Описание	Omodenbamab (JN961016) is a research-grade recombinant antibody targeting SpA. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Staphylococcus aureus
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG3-Kappa
Система экспрессии	Mammalian cells
Цель	SpA
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P02976
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	514-G-3, 514-G3, PA8-G3, 2241724-48-9
Фон	Immunoglobulin G-binding protein A (SpA) is a ~56 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. 1. Graille, M. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5399-404. PMID: 10805799 2. Moks, T. et al. (1986) European journal of biochemistry 156, 637-43. PMID: 2938951 3. Forsgren, A. et al. (1966) Journal of immunology (Baltimore, Md. : 1950) 97, 822-7. PMID: 4163007
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Omodenbamab

Ссылки

Даташит

Anti-Staphylococcus aureus SpA/Protein A Reference Antibody (Omodenbamab, RUO).pdf

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Formula

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