Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO) (HC295016)

Name: Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO)
Brand: abinScience
SKU: HC295016
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HC295016
Description	rapaprutug (HC295016) is a research-grade recombinant antibody targeting KARS1/Lysyl-tRNA synthetase. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, Kappa
Espèces	Human
Cible	KARS1/Lysyl-tRNA synthetase
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Numéro d'accès	Q15046
Forme	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	2994192-38-8
Contexte	Lysine--tRNA ligase (KARS1/Lysyl-tRNA synthetase) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. 1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264 2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479 3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442 4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690 5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237 6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539 7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739 8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO).pdf

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