Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO) (HC295016)

Name: Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO)
Brand: abinScience
SKU: HC295016
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Обзор
Изображения
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SDS

Обзор

Каталожный номер	HC295016
Описание	rapaprutug (HC295016) is a research-grade recombinant antibody targeting KARS1/Lysyl-tRNA synthetase. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, Kappa
Виды	Human
Цель	KARS1/Lysyl-tRNA synthetase
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Номер доступа	Q15046
Форма	Liquid
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	2994192-38-8
Фон	Lysine--tRNA ligase (KARS1/Lysyl-tRNA synthetase) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. 1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264 2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479 3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442 4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690 5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237 6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539 7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739 8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

SDS-PAGE

SDS-PAGE for Research Grade rapaprutug

Ссылки

Даташит

Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

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Volume

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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