Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO) (HV162016)

Name: Anti-Human Frizzled-1 Reference Antibody (Vantictumab, RUO)
Brand: abinScience
SKU: HV162016
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HV162016
Description	Vantictumab (HV162016) is a research-grade recombinant antibody targeting FzE1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG2-lambda
Système d'expression	Mammalian cells
Cible	FzE1, Frizzled-1, hFz1, Fz-1, FZD1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9UP38
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	OMP-18R5, 1345009-45-1
Contexte	Frizzled-1 (FZD1) is a ~71 kDa protein. Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. 1. Gazit, A. et al. (1999) Oncogene 18, 5959-66. PMID: 10557084
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Vantictumab.
Bioactivity

SEC-HPLC detection for Research Grade Vantictumab.
Western blot

Western blot analysis was performed using anti-FZD7 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human FZD7 (Catalog No: HF587011)
Lane 2: negative control