Anti-Human FZD1 Recombinant Antibody (SAA0167), FITC (HV162117)

Name: Anti-Human FZD1 Recombinant Antibody (SAA0167), FITC
Brand: abinScience
SKU: HV162117
Price: 223 USD
Availability: InStock

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Overview

Catalog No.	HV162117
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG2, lambda
Clone ID	SAA0167
Conjugation	FITC
Clonality	Monoclonal
Target	FzE1, Frizzled-1, hFz1, Fz-1, FZD1
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Accession	Q9UP38
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Frizzled-1 (FZD1) is a ~71 kDa protein. Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. 1. Gazit, A. et al. (1999) Oncogene 18, 5959-66. PMID: 10557084
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

Flow CytoMetry

Flow-cytometry using FITC anti-human FZD1 antibody. THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human FZD1 monoclonal antibody (Catalog: HV162117, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet