Anti-Human Integrin alpha 2/CD49b Reference Antibody (Vatelizumab, RUO) (HB772016)

Name: Anti-Human Integrin alpha 2/CD49b Reference Antibody (Vatelizumab, RUO)
Brand: abinScience
SKU: HB772016
Price: 176 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HB772016
説明	Vatelizumab (HB772016) is a research-grade recombinant antibody targeting CD49B. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4-kappa
発現システム	Mammalian cells
ターゲット	Collagen receptor, ITGA2, VLA-2 subunit alpha, CD49B, CD49 antigen-like family member B, Platelet membrane glycoprotein Ia, GPIa, Integrin alpha-2, CD49b
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P17301
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	GBR500, 1238217-55-4
背景	Integrin alpha-2 (CD49b/ITGA2) is a ~129 kDa protein. Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

イメージ

SDS-PAGE

SDS-PAGE for Research Grade Vatelizumab.
Flow CytoMetry

Flow-cytometry using APC anti-human CD49b antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD49b monoclonal antibody (Catalog: HB772016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human CD49b antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD49b monoclonal antibody (Catalog: HB772016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human CD49b antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD49b monoclonal antibody (Catalog: HB772016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.