Protein A/G purified from cell culture supernatant.
Número de acceso
Q99988
Forma
Liquid
Buffer de almacenamiento
0.01M PBS pH 7.4
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos
CTL002, CTL-002, CTL002, 2556646-63-8
Fondo
Growth/differentiation factor 15 (GDF15/MIC1) is a ~34 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.
1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844
2. Tsai, VW. et al. (2014) PloS one 9, e100370. PMID: 24971956
3. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097
4. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098
5. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099
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