Tiragolumab ELISA Kit (DS739018)

データシート製品共有情報コピー

概要
イメージ
参考文献
データシート
SDS

カタログ番号	DS739018
説明	Tiragolumab ELISA Kit (DS739018) — Quantitative sandwich ELISA for Tiragolumab. Sample: Plasma, Serum. Range: 31.25 ng/mL - 2000 ng/mL. Highlights ●Sandwich Format — High specificity, reliable quantification. ●Ready-to-Use — Complete kit with pre-coated plates included.
サンプルタイプ	Plasma, Serum
レンジ	31.25 ng/mL - 2000 ng/mL
アクセッション番号	Q495A1
アプリケーション	ELISA
検出方法	Colorimetric
アッセイタイプ	Quantitative
回収率	75-110%
発送	2-8 ℃
安定性と保存	When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20℃, the rest reagents should be store at 4℃.
仕様	Tiragolumab
別名	MTIG-7192-A, MTIG-7192A, MTIG7192A, RG-6058, RO-7092284, RO7092284, 1918185-84-8
背景	T-cell immunoreceptor with Ig and ITIM domains (Tiragolumab) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
注意事項	For Research Use Only.