SARS-CoV-2 (COVID-19) Research Reagents — Antibodies, Proteins & ELISA Kits

Spike Protein (S/S1/S2/RBD) — 304 Products — The spike glycoprotein is a homotrimeric class I fusion protein cleaved into S1 (receptor-binding) and S2 (membrane fusion) subunits. The receptor-binding domain (RBD) within S1 directly engages human ACE2 and is the dominant target for neutralizing antibodies and vaccine design. abinScience offers 304 spike-targeting reagents including recombinant RBD/S1/S2/full-length proteins (wild-type and variant-specific), neutralizing recombinant antibodies (CR3022, REGN10933, S309, and 50+ additional clones), and matched antibody pairs for sandwich ELISA development.

Nucleoprotein (N/NP) — 19 Products — Nucleoprotein is the most abundant viral protein in infected cells, making it the primary target for rapid antigen detection tests. NP is also highly immunogenic and widely used in serological IgG/IgM assays. abinScience provides recombinant NP protein (full-length, His/Fc-tagged), anti-NP monoclonal antibodies (clone 2D2, 2G7), polyclonal antibodies, and NP ELISA kits (Cat# VK575018).

Non-structural Proteins (NSP1–16, 3CLpro, PLpro, RdRp) — 27 Products — NSPs are essential for viral replication and represent key drug targets. 3CL protease (Mpro/NSP5) and papain-like protease (PLpro/NSP3) are targets for antiviral drug development (nirmatrelvir/paxlovid targets 3CLpro). RNA-dependent RNA polymerase (RdRp/NSP12) is the target of remdesivir. abinScience provides recombinant NSP proteins and detection antibodies for drug screening and mechanism studies.

Accessory Proteins (ORF3a, ORF7a, ORF8, ORF9b, ORF10) — 11 Products — Accessory proteins modulate host immune responses and viral pathogenesis. ORF8 is a rapidly evolving protein with immune evasion functions; ORF3a forms viroporins involved in inflammatory signaling. Polyclonal antibodies against these targets are available for functional studies and host-pathogen interaction research.

Host Factors (ACE2, TMPRSS2) & Stable Cell Lines — For viral entry mechanism studies and pseudovirus neutralization assays, abinScience offers recombinant human ACE2 protein and HEK293T stable cell lines expressing SARS-CoV-2 Spike (wild-type and pseudotyped), Membrane (M), Envelope (E), and Nucleoprotein (N).

Which antibody clone is recommended for SARS-CoV-2 RBD detection by ELISA?
For sandwich ELISA, we recommend pairing clone CR3022 (Cat# VK565043) as capture antibody with a polyclonal anti-RBD detection antibody. CR3022 recognizes a conserved epitope on RBD and cross-reacts with multiple SARS-CoV-2 variants. For variant-specific detection, clones such as REGN10933 and S309 provide complementary epitope coverage.

Do your spike proteins cover Omicron and other variants?
Yes. abinScience provides wild-type (Wuhan-Hu-1) spike/RBD proteins as well as variant-specific versions. Contact us with your specific variant requirements for current availability.

What is the difference between your recombinant antibodies and biosimilar-grade products?
Recombinant antibodies are research-grade reagents for detection, neutralization, and functional assays. Biosimilar-grade (Research Grade) products are sequence-identical to approved therapeutic antibodies (e.g., sotrovimab, tixagevimab) manufactured for use as reference standards in drug development, PK/ADA assays, and bioactivity benchmarking.

Explore reagents for related coronaviruses:

SARS-CoV MERS-CoV MHV IBV PDCoV PEDV