InVivoMAb Anti-Mouse IFN-gamma Antibody (R4-6A2) (MF813020)

Name: InVivoMAb Anti-Mouse IFN-gamma Antibody (R4-6A2)
Brand: abinScience
SKU: MF813020
Price: 370 USD
Availability: InStock

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Уведомление · Каталог MF813020 был прекращен.

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Спецификация:

100ug
1mg

Количество:

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SDS

Обзор

Каталожный номер

MF813020

Описание

InVivoMAb Anti-Mouse IFN-gamma Antibody (R4-6A2) (MF813020) is a rat monoclonal antibody detecting IFN-gamma in ELISA, FACS, Functional assay, Research in vivo. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Mouse

Применения

in vivo IFNγ neutralization, in vitro IFNγ neutralization

Хозяинский вид

Rat

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

R4-6A2

Цель

Interferon gamma, IFN-gamma, Immune interferon, IFNG

Уровень эндотоксинов

< 1 EU/mg as determined by LAL method.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P01580

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Interferon gamma (Interferon gamma,IFN-gamma,Immune interferon,IFNG) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093

2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937

3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687

4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024

5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687

6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559

Примечание

For research use only

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