Anti-Mouse IFNG/IFN-gamma Recombinant Antibody (XMG1.2) (MF813013)

Name: Anti-Mouse IFNG/IFN-gamma Recombinant Antibody (XMG1.2)
Brand: abinScience
SKU: MF813013
Price: 110 USD
Availability: InStock

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Overview

Catalog No.	MF813013
Species reactivity	Mouse
Applications	FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	XMG1.2
Clonality	Monoclonal
Target	Interferon gamma, IFN-gamma, Immune interferon, IFNG
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01580
RRID	Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2) (abinScience Cat# MF813013, RRID:AB_3725653)
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interferon gamma (IFNG/IFN-gamma) is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387 2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301 3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209 4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851
Note	For research use only.