InVivoMAb Anti-Mouse IFN-gamma Antibody (XMG1.2) (MF813010)

Name: InVivoMAb Anti-Mouse IFN-gamma Antibody (XMG1.2)
Brand: abinScience
SKU: MF813010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	MF813010
Description	InVivoMAb Anti-Mouse IFNG/IFN-gamma Antibody (XMG1.2) [XMG1.2] (MF813010) is a rat monoclonal antibody detecting IFN-gamma in FCM, in vivo study. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	FCM, in vivo study
Host species	Rat
Isotype	IgG
Clone ID	XMG1.2
Clonality	Monoclonal
Target	IFN-gamma, Ifng, Interferon gamma
Endotoxin level	< 1 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01580
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Interferon gamma (IFNG/IFN-gamma) is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387 2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301 3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209 4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851
Note	For research use only.