Anti-Human CD31/PECAM1 Polyclonal Antibody (HB004014)

Name: Anti-Human CD31/PECAM1 Polyclonal Antibody
Brand: abinScience
SKU: HB004014
Price: 96 USD
Availability: InStock

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概要

カタログ番号

HB004014

説明

Anti-CD31/PECAM1 Polyclonal Antibody (HB004014) is a rabbit polyclonal antibody detecting PECAM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human CD31/PECAM1 (Asp199-Lys287).

ターゲット

PECAM-1, Platelet endothelial cell adhesion molecule, GPIIA', PECAM1, PECA1, EndoCAM, CD31

精製

Purified by antigen affinity column.

アクセッション番号

P16284

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.

1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308

2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684

3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302

4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892

5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896

注意事項

For research use only.

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参考文献

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