Anti-Human CD31/PECAM1 Recombinant Antibody (SAA1541) (HB004013)

Name: Anti-Human CD31/PECAM1 Recombinant Antibody (SAA1541)
Brand: abinScience
SKU: HB004013
Price: 196 USD
Availability: InStock

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Spec:

50ug
100ug
1mg

Number:

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB004013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1541

Clonality

Monoclonal

Target

PECAM-1, Platelet endothelial cell adhesion molecule, GPIIA', PECAM1, PECA1, EndoCAM, CD31

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16284

RRID

Anti-Human CD31/PECAM1 Antibody (SAA1541) (abinScience Cat# HB004013, RRID:AB_3727302)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.

1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308

2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684

3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302

4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892

5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896

Note

For research use only.

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