Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433) (HB004035)

Name: Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433)
Brand: abinScience
SKU: HB004035
Price: 194 USD
Availability: InStock

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Overview

Catalog No.	HB004035
Description	Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433) [1A433] (HB004035) is a mouse monoclonal antibody detecting PECAM1 in ELISA. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
Species reactivity	Human
Applications	ELISA
Host species	Mouse
Isotype	IgG2a
Clone ID	1A433
Clonality	Monoclonal
Immunogen	Recombinant Human CD31/PECAM1 protein.
Target	Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1
Purification	Protein A/G purified from cell culture supernatant.
Accession	P16284
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. 1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684 3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302 4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892 5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
Note	For research use only.