Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) (HB004025)

Name: Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168)
Brand: abinScience
SKU: HB004025
Price: 194 USD
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Número de catálogo	HB004025
Descripción	Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) [1A168] (HB004025) is a mouse monoclonal antibody detecting PECAM1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Reactividad de especies	Human
Aplicaciones	ELISA, IHC, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	1A168
Inmunógeno	Mammalian cells - derived recombinant Human CD31 / PECAM1 (Met1-Lys601).
Objetivo	PECAM-1, Platelet endothelial cell adhesion molecule, GPIIA', PECAM1, PECA1, EndoCAM, CD31,
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P16284
Forma	Liquid
Buffer de almacenamiento	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium azide. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. 1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684 3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302 4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892 5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
Nota	For research use only.