Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) (HB004025)

Name: Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168)
Brand: abinScience
SKU: HB004025
Price: 194 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

50ug
100ug

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HB004025
Описание	Anti-Human CD31/PECAM1 Monoclonal Antibody (1A168) [1A168] (HB004025) is a mouse monoclonal antibody detecting PECAM1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	1A168
Иммуноген	Mammalian cells - derived recombinant Human CD31 / PECAM1 (Met1-Lys601).
Цель	PECAM-1, Platelet endothelial cell adhesion molecule, GPIIA', PECAM1, PECA1, EndoCAM, CD31,
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P16284
Форма	Liquid
Буфер хранения	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium azide. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. 1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308 2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684 3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302 4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892 5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
Примечание	For research use only.