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| カタログ番号 | HB018013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1615 | ||||
| ターゲット | IA4, Tspan-27, Metastasis suppressor Kangai-1, Inducible membrane protein R2, Suppressor of tumorigenicity 6 protein, KAI1, TSPAN27, CD82, SAR2, C33 antigen, ST6, Tetraspanin-27, CD82 antigen | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P27701 | ||||
| RRID | Anti-Human CD82 Antibody (SAA1615) (abinScience Cat# HB018013, RRID:AB_3727376) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | CD82 antigen is a ~29 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. 1. Xu, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 3273-88. PMID: 19497983 2. Odintsova, E. et al. (2000) Current biology : CB 10, 1009-12. PMID: 10985391 3. Bu, J. et al. (2022) Acta biochimica et biophysica Sinica 54, 400-408. PMID: 35538033 4. Odintsova, E. et al. (2013) The Journal of biological chemistry 288, 26323-26334. PMID: 23897813 5. Termini, CM. et al. (2014) Molecular biology of the cell 25, 1560-73. PMID: 24623721 6. Mannion, BA. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 157, 2039-47. PMID: 8757325 7. He, B. et al. (2005) The Journal of biological chemistry 280, 3346-54. PMID: 15557282 8. Jee, BK. et al. (2007) Biochemical and biophysical research communications 359, 703-8. PMID: 17560548 9. Bass, R. et al. (2005) The Journal of biological chemistry 280, 14811-8. PMID: 15677461 10. Lee, H. et al. (2023) BMB reports 56, 359-364. PMID: 36945827 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human CD82 Antibody (SAA1615)
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