Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033)

Name: Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2)
Brand: abinScience
SKU: HA089033
Price: 126 USD
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Numéro de catalogue	HA089033
Description	Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033) is a mouse monoclonal antibody detecting R-Spondin 2 in Blocking, in vitro, in vivo, SPR. Suitable for Human, Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications. ●Multi-Species — Cross-reactive for translational research.
Reactivité des espèces	Human, Mouse
Applications	Blocking, in vitro, in vivo, SPR
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	h130M23-H1L2
Cible	Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q6UXX9
RRID	Anti-Human RSPO2 Recombinant Antibody (h130M23-H1L2) (abinScience Cat# HA089033, RRID:AB_3729850)
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form. 1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895 2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076 3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920 4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720
Note	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2).pdf

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Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L2) (HA089033)

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