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| カタログ番号 | HC445013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | DB, ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | 3H | ||||
| ターゲット | TARDBP, TDP43, TAR DNA-binding protein 43, TDP-43 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q13148 | ||||
| RRID | Anti-Human TARDBP/TDP43 Antibody (3H) (abinScience Cat# HC445013, RRID:AB_3727138) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
| ||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | TAR DNA-binding protein 43 (TARDBP/TDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. 1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609 2. Lukavsky, PJ. et al. (2013) Nature structural & molecular biology 20, 1443-9. PMID: 24240615 3. Kuo, PH. et al. (2014) Nucleic acids research 42, 4712-22. PMID: 24464995 4. Tollervey, JR. et al. (2011) Nature neuroscience 14, 452-8. PMID: 21358640 5. Wang, A. et al. (2018) The EMBO journal 37. PMID: 29438978 6. Izumikawa, K. et al. (2017) Scientific reports 7, 7709. PMID: 28794432 7. Fukushima, M. et al. (2019) FEBS letters 593, 277-287. PMID: 30520513 8. Colombrita, C. et al. (2009) Journal of neurochemistry 111, 1051-61. PMID: 19765185 9. Higashi, S. et al. (2013) Journal of neurochemistry 126, 288-300. PMID: 23398327 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human TARDBP/TDP43 Antibody (3H)
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