Human Nectin-2/CD112 Recombinant Protein (C-His) (HV456011)

Name: Human Nectin-2/CD112 Recombinant Protein (C-His)
Brand: abinScience
SKU: HV456011
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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SDS

Vista general

Número de catálogo	HV456011
Descripción	Recombinant Human CD112/Nectin-2/PVRL2 Protein, C-His (HV456011) expressed in Mammalian Cells, spanning Met1-Leu360. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	Q92692
Longitud de proteína	Met1-Leu360
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Aplicaciones probadas	WB
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	39.79 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Herpesvirus entry mediator B, Herpes virus entry mediator B, Nectin cell adhesion molecule 2, HVEB, PVRL2, Poliovirus receptor-related protein 2, CD112, PRR2, Nectin-2, HveB, NECTIN2
Fondo	Nectin-2 (CD112/PVRL2) is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. 1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005
Nota	For research use only.

Imágenes

Bioactivity

Detects Human CD112/Nectin-2/PVRL2 Antibody (SAA0405) in indirect ELISAs.
Western blot

Detected by Anti-CD112/Nectin-2/PVRL2 monoclonal antibody (Catalog No: HV456107)
Bioactivity

Detected by Research Grade Anti-Human CD112/Nectin-2/PVRL2 Antibody (NTX-1107C) (Catalog No: HP700046) in indirect ELISA
Bioactivity

Detected by Anti-Human CD112/Nectin-2/PVRL2 Antibody (SAA2115) (Catalog No: HV456207) in indirect ELISA
Bioactivity

Detected by SAA2116 (Catalog No: HV456023) in indirect ELISA
Bioactivity

Detected by SAA2117 (Catalog No: HV456033) in indirect ELISA
Bioactivity

Detected by SAA2364 (Catalog No: HV456013) in indirect ELISA
Bioactivity

Immobilized HV456011 Human CD112/Nectin-2/PVRL2 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HS737021 Human CD226/DNAM-1 Recombinant Protein (C-Fc), the EC 50 is 28.8 μg/mL.