Anti-Human CD112/Nectin-2/PVRL2 Reference Antibody (NTX-1107C, RUO) (HP700046)

Name: Anti-Human CD112/Nectin-2/PVRL2 Reference Antibody (NTX-1107C, RUO)
Brand: abinScience
SKU: HP700046
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HP700046
Description	Research Grade Anti-Human CD112/Nectin-2/PVRL2 Antibody (NTX-1107C) [NTX-1107C] (HP700046) is a mouse monoclonal antibody detecting Nectin-2 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	NTX-1107C
Clonality	Monoclonal
Target	Nectin-2, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2, CD112, NECTIN2, HVEB, PRR2, PVRL2
Endotoxin level	< 1EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q92692
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Nectin-2 (CD112/PVRL2) is a ~57 kDa protein. Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. 1. Zhu, Y. et al. (2016) The Journal of experimental medicine 213, 167-76. PMID: 26755705 2. Warner, MS. et al. (1998) Virology 246, 179-89. PMID: 9657005
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD112/Nectin-2/PVRL2 Antibody (NTX-1107C)
Bioactivity

Detects recombinant human CD112/Nectin-2/PVRL2 (Catalog No: HV456011) in indirect ELISA
Western blot

Western blot analysis was performed using anti-CD112/Nectin-2/PVRL2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD112/Nectin-2/PVRL2 (Catalog No: HV456011)
Lane 2: negative control
Lane 3: negative control