Thyroid & Pituitary Hormone Research Reagents

The hypothalamic-pituitary-thyroid (HPT) axis and broader pituitary endocrine system regulate metabolism, growth, reproduction, and stress response. Thyroid function tests (TSH, free T4, free T3) are the most frequently ordered endocrine immunoassays in clinical laboratories worldwide, while pituitary hormones (growth hormone, prolactin, ACTH) are central to diagnosing pituitary adenomas, growth disorders, and adrenal insufficiency. Developing and optimizing these high-volume immunoassays requires rigorously characterized calibrator proteins and matched antibody pairs.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

abinScience provides validated antibodies, recombinant proteins, and ELISA kits for key thyroid and pituitary hormone targets. Recombinant hormone proteins serve as immunoassay calibrators and standards. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom development.

For thyroid autoimmune research targets (anti-TPO, anti-Tg, TRAb) related to Hashimoto’s thyroiditis and Graves’ disease, see Hashimoto’s Thyroiditis and Hyperthyroidism, Graves’ Disease under Autoimmune Diseases.

Thyroid Axis

TSH (Thyroid-Stimulating Hormone / Thyrotropin) — A 28 kDa glycoprotein heterodimer (α/β subunits) secreted by anterior pituitary thyrotropes. TSH is the first-line screening biomarker for thyroid dysfunction — elevated in hypothyroidism, suppressed in hyperthyroidism. Third-generation TSH immunoassays with functional sensitivity ≤0.02 mIU/L are the clinical standard. Recombinant TSH proteins serve as calibrators; matched monoclonal antibody pairs targeting the β-subunit confer specificity against the shared α-subunit (common to FSH, LH, hCG).
→ Browse TSH antibodies & proteins

T3 (Triiodothyronine) / T4 (Thyroxine) — The biologically active thyroid hormones. T4 is the predominant circulating form produced by the thyroid gland; T3 is generated peripherally by deiodinase-mediated T4 conversion and is 3–5x more potent. Free T4 and free T3 immunoassays measure the unbound, biologically available fraction. Recombinant thyroid hormone-binding proteins and hapten-conjugated antigens support assay development for competitive immunoassay platforms.
→ Browse T3 / T4 antibodies & proteins

Anterior Pituitary Hormones

Growth Hormone (GH / Somatotropin / GH1) — A 22 kDa polypeptide secreted in pulsatile fashion by pituitary somatotropes. GH drives linear growth via hepatic IGF-1 production and directly regulates lipid metabolism, body composition, and glucose homeostasis. GH excess causes acromegaly; deficiency causes growth failure in children. Recombinant GH proteins support growth hormone stimulation test standardization and bioassay development.
→ Browse Growth Hormone antibodies & proteins

Prolactin (PRL) — Pituitary hormone primarily known for lactation initiation but with over 300 identified biological activities spanning immune modulation, osmoregulation, and reproductive function. Hyperprolactinemia is the most common pituitary hormone abnormality, frequently caused by prolactinomas. Prolactin immunoassays must account for macroprolactin (big-big PRL) interference, requiring antibodies that distinguish monomeric bioactive PRL from high-molecular-weight complexes.
→ Browse Prolactin antibodies & proteins

ACTH (Adrenocorticotropic Hormone / Corticotropin) — A 39-amino-acid peptide cleaved from proopiomelanocortin (POMC) by pituitary corticotropes. ACTH stimulates adrenal cortisol secretion and is the key diagnostic analyte for differentiating Cushing’s disease (pituitary ACTH excess) from adrenal Cushing’s syndrome (ACTH-independent) and ectopic ACTH secretion. ACTH is notoriously unstable in plasma, making well-characterized recombinant standards and stabilized antibody pairs critical for reliable measurement.
→ Browse ACTH antibodies & proteins

References

1. Jonklaas J, et al. Guidelines for the treatment of hypothyroidism. Thyroid. 2014;24(12):1670-1751. DOI

2. Spencer CA, et al. Current thyroglobulin autoantibody (TgAb) assays often fail to detect interfering TgAb that can result in the reporting of falsely low Tg IMA values for patients with differentiated thyroid cancer. J Clin Endocrinol Metab. 2011;96(5):1283-1291. DOI

3. Molitch ME. Diagnosis and treatment of pituitary adenomas: a review. JAMA. 2017;317(5):516-524. DOI

4. Nieman LK, et al. The diagnosis of Cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2008;93(5):1526-1540. DOI