Notch Signaling Pathway Research Reagents

The Notch pathway is an evolutionarily conserved cell-cell contact signaling mechanism that regulates cell fate decisions, proliferation, and differentiation. Ligand binding (DLL1/4, Jagged1/2) on a signal-sending cell triggers sequential proteolytic cleavage of the Notch receptor — first by ADAM10/17 metalloproteases, then by γ-secretase — releasing the Notch intracellular domain (NICD) for nuclear translocation and activation of HES/HEY family target genes. Aberrant Notch signaling is implicated in T-ALL, breast cancer, pancreatic cancer, and vascular development disorders.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

abinScience provides recombinant proteins and antibodies for key Notch signaling targets — receptors, ligands, and associated proteins. Available in His-tag, Fc-tag, and fluorophore-conjugated formats. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom development.

Notch Receptors

Notch1 — The most extensively studied Notch receptor. Gain-of-function mutations in NOTCH1 are found in over 50% of T-ALL cases. Recombinant Notch1 extracellular domain proteins support ligand-binding studies and γ-secretase inhibitor screening.
→ Browse Notch1 antibodies & proteins

Notch2 — Plays a critical role in marginal zone B cell development and bile duct morphogenesis. NOTCH2 mutations are associated with Hajdu-Cheney syndrome and splenic marginal zone lymphoma.
→ Browse Notch2 antibodies & proteins

Notch3 — Predominantly expressed in vascular smooth muscle cells. NOTCH3 mutations cause CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts), the most common hereditary cause of stroke and vascular dementia.
→ Browse Notch3 antibodies & proteins

Notch Ligands

DLL4 (Delta-Like Ligand 4) — A key regulator of angiogenic sprouting and tip/stalk cell selection. DLL4-Notch1 signaling is a validated therapeutic target in tumor angiogenesis. Fc-tagged DLL4 proteins are recommended for plate-immobilized Notch activation assays.
→ Browse DLL4 antibodies & proteins

DLL1 (Delta-Like Ligand 1) — Essential for somitogenesis, T cell lineage commitment in the thymus, and maintenance of intestinal stem cell homeostasis.
→ Browse DLL1 antibodies & proteins

Jagged1 (JAG1) — A Serrate-family Notch ligand involved in Alagille syndrome (bile duct paucity), hematopoietic stem cell maintenance, and tumor-stromal Notch signaling. Jagged1-Notch2 interaction is critical for marginal zone B cell development.
→ Browse Jagged1 antibodies & proteins

References

1. Bray SJ. Notch signalling in context. Nat Rev Mol Cell Biol. 2016;17(11):722-735. DOI

2. Weng AP, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306(5694):269-271. DOI

3. Noguera-Troise I, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006;444(7122):1032-1037. DOI

4. Joutel A, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 1996;383(6602):707-710. DOI