Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014)

Name: Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody
Brand: abinScience
SKU: MW574014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

MW574014

설명

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014) is a rabbit polyclonal antibody detecting CHOP/GADD153/DDIT3 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse CHOP/GADD153/DDIT3 (Met1-Ala168).

타겟

C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, CHOP, CHOP-10, CHOP10, DDIT-3, DDIT3, DNA damage-inducible transcript 3 protein, GADD153, Growth arrest and DNA damage-inducible protein GADD153

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P35639

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

DNA damage-inducible transcript 3 protein (CHOP/GADD153) is a ~19 kDa protein. Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

1. Yamaguchi, H. et al. (2004) The Journal of biological chemistry 279, 45495-502. PMID: 15322075

2. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988

3. Oliveira, SJ. et al. (2009) PloS one 4, e6618. PMID: 19672300

4. Vij, N. et al. (2008) American journal of respiratory cell and molecular biology 38, 176-84. PMID: 17709599

5. Goodall, JC. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 17698-703. PMID: 20876114

6. Ghosh, AP. et al. (2012) PloS one 7, e39586. PMID: 22761832

7. Su, N. et al. (2008) The Journal of biological chemistry 283, 35106-17. PMID: 18940792

8. Park, SH. et al. (2010) The Journal of biological chemistry 285, 35330-9. PMID: 20829347

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014)

개요

이미지

참고 문헌

데이터시트

SDS

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