Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody (MB251014)

Name: Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody
Brand: abinScience
SKU: MB251014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MB251014

설명

Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody (MB251014) is a rabbit polyclonal antibody detecting Integrin beta 6/ITGB6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse ITGB6 (Tyr131-Ser373).

타겟

ITGB6, Integrin beta-6

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q9Z0T9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Integrin beta-6 (ITGB6) is a ~85 kDa protein. Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.

1. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881

2. Ramsay, AG. et al. (2007) Cancer research 67, 5275-84. PMID: 17545607

3. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403

4. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742

5. Dong, X. et al. (2017) Nature 542, 55-59. PMID: 28117447

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody (MB251014)

개요

이미지

참고 문헌

데이터시트

SDS

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