Anti-African clawed frog IRF3 Polyclonal Antibody (ZC458014)

Name: Anti-African clawed frog IRF3 Polyclonal Antibody
Brand: abinScience
SKU: ZC458014
Price: 168 USD
Availability: InStock

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100ug

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

ZC458014

설명

Anti-African clawed frog IRF3 Polyclonal Antibody (ZC458014) is a rabbit polyclonal antibody detecting IRF3 in ELISA, IHC, WB. Suitable for Xenopus laevis (African clawed frog).

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Xenopus laevis (African clawed frog)

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant African clawed frog IRF3 (Met1-Thr124).

타겟

IRF-3, IRF3, Interferon regulatory factor 3

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q7ZXG6

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Interferon regulatory factor 3 (IRF3) is a ~47 kDa protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.

1. Tanaka, Y. et al. (2012) Science signaling 5, ra20. PMID: 22394562

2. Wang, S. et al. (2013) Journal of virology 87, 12814-27. PMID: 24049179

3. Liu, S. et al. (2015) Science (New York, N.Y.) 347, aaa2630. PMID: 25636800

4. Zhao, B. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E3403-12. PMID: 27302953

5. Li, D. et al. (2019) Journal of cell science 133. PMID: 31340999

6. Yang, S. et al. (2023) Molecular cell 83, 298-313.e8. PMID: 36603579

7. Au, WC. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 11657-61. PMID: 8524823

8. Zhu, H. et al. (2024) Cell death & disease 15, 727. PMID: 39362857

9. Yoneyama, M. et al. (2002) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 22, 73-6. PMID: 11846977

10. Solis, M. et al. (2006) Biochemical pharmacology 72, 1469-76. PMID: 16846591

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-African clawed frog IRF3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-African clawed frog IRF3 Polyclonal Antibody (ZC458014)

개요

이미지

참고 문헌

데이터시트

SDS