InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010)

Name: InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25)
Brand: abinScience
SKU: MY408010
Price: 191 USD
Availability: InStock

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100ug
1mg

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개요

카탈로그 번호	MY408010
설명	InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010) is a mouse monoclonal antibody detecting IL-7 in in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation. Suitable for Human, Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications. ●Multi-Species — Cross-reactive for translational research.
종 반응성	Human, Mouse
응용 분야	in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2b, kappa
클론 ID	M25
타겟	IL-7, Il-7, Il7, Interleukin-7
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P10168
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Interleukin-7 (IL7) is a ~20 kDa protein. Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5. 1. Bazdar, DA. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 4698-704. PMID: 25870237 2. Dittel, BN. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 58-67. PMID: 7527823 3. Kondo, M. et al. (1994) Science (New York, N.Y.) 263, 1453-4. PMID: 8128231 4. Johnson, SE. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 8109-17. PMID: 18523275 5. Rochman, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19455-60. PMID: 20974963
참고사항	For research use only

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InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25).pdf

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InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010)

개요

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