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| 카탈로그 번호 | MB768012 |
|---|---|
| 설명 |
Recombinant Mouse HSD11B1 Protein, N-His (MB768012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P50172 |
| 단백질 길이 | Glu25-Asn292 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Mus musculus (Mouse) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 11-DH, 11-beta-HSD1, 11-beta-HSD1A/MCR, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase, 11beta-HSD1A, 7-oxosteroid reductase, Corticosteroid 11-beta-dehydrogenase isozyme 1, EC:1.1.1.146, EC:1.1.1.201, Hsd11, Hsd11b1, liver-type 11-beta-HSD |
| 배경 | 11-beta-hydroxysteroid dehydrogenase 1 is a ~32 kDa protein. Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes. Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids. It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates. Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others. 1. Mitić, T. et al. (2013) Biochemical pharmacology 86, 146-53. PMID: 23415904 2. Beck, KR. et al. (2019) The Journal of steroid biochemistry and molecular biology 190, 19-28. PMID: 30902677 3. Kotelevtsev, Y. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 14924-9. PMID: 9405715 |
| 참고사항 | For research use only |
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