Mouse IL6ST Recombinant Protein (N-His) (MW398012)

Name: Mouse IL6ST Recombinant Protein (N-His)
Brand: abinScience
SKU: MW398012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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개요

카탈로그 번호	MW398012
설명	Recombinant Mouse IL6ST Protein, N-His (MW398012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	Q00560
단백질 길이	Glu26-Asp213
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Mus musculus (Mouse)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, Il6st
배경	Interleukin-6 receptor subunit beta is a ~102 kDa protein. Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. 1. Saito, M. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 148, 4066-71. PMID: 1602143 2. Ohtani, T. et al. (2000) Immunity 12, 95-105. PMID: 10661409 3. Starr, R. et al. (1997) Nature 387, 917-21. PMID: 9202125 4. Taniguchi, K. et al. (2015) Nature 519, 57-62. PMID: 25731159 5. Malsch, P. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 9845-56. PMID: 25057188 6. Johnson, RW. et al. (2015) Bone 81, 343-351. PMID: 26255596 7. Yoshida, K. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 407-11. PMID: 8552649
참고사항	For research use only

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Mouse IL6ST Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mouse IL6ST Recombinant Protein (N-His) (MW398012)

개요

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