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| 카탈로그 번호 | HT036014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-ABCC3 Polyclonal Antibody (HT036014) is a rabbit polyclonal antibody detecting ABCC3/MRP3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ABCC3 (Phe1291-Asp1523). | ||||||||
| 타겟 | ABCC3, MRP3, MOAT-D, CMOAT2, Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multidrug resistance-associated protein 3, Multi-specific organic anion transporter D, MLP2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O15438 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | ATP-binding cassette sub-family C member 3 (ABCC3/MRP3) is a ~169 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). 1. Kool, M. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 6914-9. PMID: 10359813 2. Zelcer, N. et al. (2001) The Journal of biological chemistry 276, 46400-7. PMID: 11581266 3. Lee, YM. et al. (2004) Pharmacogenetics 14, 213-23. PMID: 15083066 | ||||||||
| 참고사항 | For research use only. |
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