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| 카탈로그 번호 | HA690014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-ABCD1 Polyclonal Antibody (HA690014) is a rabbit polyclonal antibody detecting ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy protein; ALDP; ABCD1; ALD in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human ABCD1 (Leu461-Thr745). | ||||||||
| 타겟 | ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy protein; ALDP; ABCD1; ALD | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P33897, P48410, D3ZHR2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | ATP-binding cassette sub-family D member 1 (ABCD1) is a ~82 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. 1. Roerig, P. et al. (2001) FEBS letters 492, 66-72. PMID: 11248239 2. Guimarães, CP. et al. (2005) Journal of human genetics 50, 99-105. PMID: 15682271 3. Morita, M. et al. (2006) Biological & pharmaceutical bulletin 29, 1836-42. PMID: 16946495 4. van Roermund, CW. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 4201-8. PMID: 18757502 5. van Roermund, CW. et al. (2011) Biochimica et biophysica acta 1811, 148-52. PMID: 21145416 6. Wiesinger, C. et al. (2013) The Journal of biological chemistry 288, 19269-79. PMID: 23671276 7. Okamoto, T. et al. (2018) Biochemical and biophysical research communications 496, 1122-1127. PMID: 29397936 8. Kawaguchi, K. et al. (2021) Scientific reports 11, 2192. PMID: 33500543 | ||||||||
| 참고사항 | For research use only |
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