Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

Name: Anti-ABRAXAS2 Polyclonal Antibody
Brand: abinScience
SKU: HB533014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HB533014

설명

Anti-ABRAXAS2 Polyclonal Antibody (HB533014) is a rabbit polyclonal antibody detecting BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human ABRAXAS2 (Met1-Ile158).

타겟

BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q15018, Q3TCJ1, A6QLR3

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

BRISC complex subunit Abraxas 2 (ABRAXAS2) is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression.

1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193

2. Cooper, EM. et al. (2010) The Journal of biological chemistry 285, 10344-52. PMID: 20032457

3. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690

4. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

5. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665

6. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097

7. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-ABRAXAS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

개요

이미지

참고 문헌

데이터시트

SDS