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| 카탈로그 번호 | HX989014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-ADK Polyclonal Antibody (HX989014) is a rabbit polyclonal antibody detecting ADK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ADK (Ile94-Ala339). | ||||||||
| 타겟 | Adenosine 5'-phosphotransferase, ADK, AK, Adenosine kinase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P55263 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Adenosine kinase (ADK) is a ~40 kDa protein. Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL. 1. Bjursell, MK. et al. (2011) American journal of human genetics 89, 507-15. PMID: 21963049 2. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445 3. Palella, TD. et al. (1980) The Journal of biological chemistry 255, 5264-9. PMID: 6246102 4. Spychala, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 1232-7. PMID: 8577746 5. McNally, T. et al. (1997) Biochemical and biophysical research communications 231, 645-50. PMID: 9070863 | ||||||||
| 참고사항 | For research use only. |
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