Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

Name: Anti-AIFM1/AIF Polyclonal Antibody
Brand: abinScience
SKU: HF658014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HF658014

설명

Anti-AIFM1/AIF Polyclonal Antibody (HF658014) is a rabbit polyclonal antibody detecting AIFM1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human AIFM1/AIF (Leu102-Asp613).

타겟

AIFM1, AIF, Programmed cell death protein 8, PDCD8, Apoptosis-inducing factor 1, mitochondrial

정제

Purified by antigen affinity column.

등록번호

O95831

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Apoptosis-inducing factor 1, mitochondrial (AIFM1/AIF) is a ~66 kDa protein. Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA.

1. Kim, JT. et al. (2006) FEBS letters 580, 6375-83. PMID: 17094969

2. Ghezzi, D. et al. (2010) American journal of human genetics 86, 639-49. PMID: 20362274

3. Rinaldi, C. et al. (2012) American journal of human genetics 91, 1095-102. PMID: 23217327

4. Mashimo, M. et al. (2021) The Journal of biological chemistry 296, 100046. PMID: 33168626

5. Sevrioukova, IF. (2016) Journal of molecular biology 428, 3650-65. PMID: 27178839

6. Son, YO. et al. (2009) Apoptosis : an international journal on programmed cell death 14, 796-808. PMID: 19418225

7. Hangen, E. et al. (2015) Molecular cell 58, 1001-14. PMID: 26004228

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-AIFM1/AIF Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-AIFM1/AIF Polyclonal Antibody (HF658014)

개요

이미지

참고 문헌

데이터시트

SDS

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