Anti-ALDH1A1 Polyclonal Antibody (HF669014)

Name: Anti-ALDH1A1 Polyclonal Antibody
Brand: abinScience
SKU: HF669014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HF669014

설명

Anti-ALDH1A1 Polyclonal Antibody (HF669014) is a rabbit polyclonal antibody detecting ALDH1A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ALDH1A1 (Met1-Ser501).

타겟

Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, ALDH-E1, RalDH1, Aldehyde dehydrogenase family 1 member A1, ALDH1A1, ALDH1, RALDH 1, ALDC, ALHDII, PUMB1

정제

Purified by antigen affinity column.

등록번호

P00352

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a ~54 kDa protein. Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.

1. Manzer, R. et al. (2003) DNA and cell biology 22, 329-38. PMID: 12941160

2. Choudhary, S. et al. (2005) Investigative ophthalmology & visual science 46, 259-67. PMID: 15623782

3. Collard, F. et al. (2007) Biochimie 89, 369-73. PMID: 17175089

4. Xiao, T. et al. (2009) Journal of toxicology and environmental health. Part A 72, 577-84. PMID: 19296407

5. Morgan, CA. et al. (2015) Chemico-biological interactions 234, 29-37. PMID: 25450233

6. Koch, MF. et al. (2015) Angewandte Chemie (International ed. in English) 54, 13550-4. PMID: 26373694

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-ALDH1A1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-ALDH1A1 Polyclonal Antibody (HF669014)

개요

이미지

참고 문헌

데이터시트

SDS

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