Anti-Human MIS/AMH Polyclonal Antibody (HY076014)

Name: Anti-Human MIS/AMH Polyclonal Antibody
Brand: abinScience
SKU: HY076014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HY076014

설명

Anti-AMH Polyclonal Antibody (HY076014) is a rabbit polyclonal antibody detecting AMH in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human AMH (Ala453-Arg560).

타겟

MIF, AMH, Muellerian-inhibiting factor, Muellerian-inhibiting substance, MIS, Anti-Muellerian hormone

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P03971

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Anti-Muellerian hormone (AMH) is a ~59 kDa protein. The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions. Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction. Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation. In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Also plays a role in Leydig cell differentiation and function.

1. Weenen, C. et al. (2004) Molecular human reproduction 10, 77-83. PMID: 14742691

2. Hart, KN. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155118

3. Cate, RL. et al. (1986) Cell 45, 685-98. PMID: 3754790

4. Wilson, CA. et al. (1993) Molecular endocrinology (Baltimore, Md.) 7, 247-57. PMID: 8469238

5. di Clemente, N. et al. (2010) Molecular endocrinology (Baltimore, Md.) 24, 2193-206. PMID: 20861221

참고사항

For research use only.

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