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| 카탈로그 번호 | MV404014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Apelin/APLN Polyclonal Antibody (MV404014) is a rabbit polyclonal antibody detecting Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel in ELISA, IHC, WB. Suitable for Rat and Mouse.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant mouse Apelin/APLN (Val23-Phe77). | ||||||||
| 타겟 | Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9R0R3, Q9R0R4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Apelin (APLN) is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions. 1. Kawamata, Y. et al. (2001) Biochimica et biophysica acta 1538, 162-71. PMID: 11336787 2. Reaux, A. et al. (2001) Journal of neurochemistry 77, 1085-96. PMID: 11359874 3. Perjés, Á. et al. (2016) Basic research in cardiology 111, 2. PMID: 26611206 4. Lee, DK. et al. (2000) Journal of neurochemistry 74, 34-41. PMID: 10617103 | ||||||||
| 참고사항 | For research use only |
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