Anti-APPL1 Polyclonal Antibody (HV723014)

Name: Anti-APPL1 Polyclonal Antibody
Brand: abinScience
SKU: HV723014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HV723014

설명

Anti-APPL1 Polyclonal Antibody (HV723014) is a rabbit polyclonal antibody detecting APPL1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human APPL1 (Phe404-Ser673).

타겟

APPL1, Dip13-alpha, APPL, DIP13A, DCC-interacting protein 13-alpha, KIAA1428, Adapter protein containing PH domain, PTB domain and leucine zipper motif 1

정제

Purified by antigen affinity column.

등록번호

Q9UKG1

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

DCC-interacting protein 13-alpha (APPL1) is a ~79 kDa protein. Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages.

1. Mitsuuchi, Y. et al. (1999) Oncogene 18, 4891-8. PMID: 10490823

2. Miaczynska, M. et al. (2004) Cell 116, 445-56. PMID: 15016378

3. Wang, C. et al. (2009) The Journal of biological chemistry 284, 31608-15. PMID: 19661063

4. Prudente, S. et al. (2015) American journal of human genetics 97, 177-85. PMID: 26073777

5. Song, J. et al. (2016) Oncotarget 7, 279-92. PMID: 26583432

6. Cheng, KK. et al. (2014) Diabetes 63, 3748-58. PMID: 24879834

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-APPL1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-APPL1 Polyclonal Antibody (HV723014)

개요

이미지

참고 문헌

데이터시트

SDS

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