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| 카탈로그 번호 | HY315014 | ||||||||
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| 설명 |
Anti-AR Polyclonal Antibody (HY315014) is a rabbit polyclonal antibody detecting AR in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Crocuta crocuta.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human AR (Leu660-Thr919). | ||||||||
| 타겟 | Dihydrotestosterone receptor, NR3C4, DHTR, Androgen receptor, AR, Nuclear receptor subfamily 3 group C member 4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P10275 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Androgen receptor (AR) is a ~99 kDa protein. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. 1. Yang, J. et al. (2009) Endocrine-related cancer 16, 139-53. PMID: 19022849 2. Cui, J. et al. (2011) Cellular and molecular life sciences : CMLS 68, 1091-103. PMID: 20812024 | ||||||||
| 참고사항 | For research use only. |
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